Midazole is used for treating certain parasitic and bacterial infections. Midazole is an antiprotozoal and antibiotic. It works by killing sensitive parasites and bacteria.
Use Midazole as directed by your doctor.
- Take Midazole by mouth with food.
- If you have trouble swallowing the tablets, check with your doctor or pharmacist.
- If you take cholestyramine, do not take it at the same time you take Midazole. Talk with your doctor about how you should take cholestyramine with Midazole.
- If more than one dose of Midazole is required, continue using Midazole for the full course of treatment in order to clear up your infection completely, even if you feel better in a few days. Do not miss any dose.
- If you miss a dose of Midazole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Midazole.
Store Midazole at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Midazole out of the reach of children and away from pets.
Do NOT use Midazole if:
- you are allergic to any ingredient in Midazole or to other nitroimidazole medicines (metronidazole)
- you have the blood disease porphyria
- you are in your first 3 months of pregnancy
- you are taking astemizole, busulfan, cisapride, or terfenadine
- you have taken disulfiram within the past 2 weeks.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Midazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have nerve, brain, or blood problems; a yeast infection; or a history of seizures or liver problems
- if you are undergoing dialysis.
Some medicines may interact with Midazole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Azole antifungals (eg, ketoconazole) or cimetidine because they may increase the risk of Midazole's side effects
- Barbiturates (eg, phenobarbital), phenytoin, or rifampin because they may decrease Midazole's effectiveness
- Anticoagulants (eg, warfarin), astemizole, busulfan, cisapride, cyclosporine, fluorouracil, lithium, macrolide immunosuppressants (eg, tacrolimus), sulfonylureas (eg, glipizide), or terfenadine because their actions and the risk of their side effects may be increased
- Disulfiram because side effects, such as mental or mood changes, may occur
- Oral contraceptives (birth control pills) because their effectiveness may be decreased by Midazole.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Midazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Important Midazole Safety Information
- Midazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Midazole with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
- Avoid drinking alcohol or taking products that contain alcohol while taking Midazole and for 3 days after the last dose.
- Midazole only works against bacteria and parasites; it does not treat viral infections (eg, the common cold).
- Be sure to use Midazole for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria or parasites could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Midazole may discolor or darken the urine. This is normal and not a cause for concern.
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Midazole. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Tell your doctor or dentist that you take Midazole before you receive any medical or dental care, emergency care, or surgery.
- Midazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Midazole.
- Lab tests, including blood cell counts, may be performed while you use Midazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Midazole with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.
- Pregnancy and breast-feeding: Midazole may cause harm to the fetus. Midazole should not be used during the first trimester of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Midazole while you are pregnant. Midazole is found in breast milk. Do not breast-feed while taking Midazole and for 3 days after you have taken the last dose.
All medicines may cause side effects, but many people have no, or minor, side effects.
Check with your doctor if any of these most common side effects persist or become bothersome:
Constipation; diarrhea; dizziness; general body discomfort; headache; loss of appetite; metallic/bitter taste in mouth; nausea; stomach pain; tiredness; vomiting; weakness.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal skin sensations (prickling, tingling); depression; fever, chills, or persistent sore throat; hoarseness; irregular heartbeat; numbness or loss of feeling in the hands or feet; pounding in the chest; red, swollen, blistered, or peeling skin; seizures; shortness of breath; unusual bruising or bleeding ; vaginal irritation or discharge.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.